Technical Advantages and Application Value
Peristaltic pumps demonstrate unique technical advantages in pharmaceutical coating and granulation processes, becoming critical equipment for modern pharmaceutical production. Their seal-free design completely eliminates cross-contamination risks, meeting stringent GMP requirements, particularly suitable for high-value API and formulation manufacturing.
Core Application Scenarios
- Precision Coating Solution Delivery
- Achieves accurate flow control of 0.5-50mL/min
- Uniform delivery of coating suspensions with 5-15% solid content
- Typical application: Aqueous/organic film coating for sustained-release formulations
- Quantitative Binder Solution Addition
- Stable delivery of HPMC, PVP binders (viscosity ≤5000cPs)
- Pulsed addition synchronized with granulator speed
- Case study: A pharma company improved binder addition accuracy to ±1.5% in wet granulation
- Safe Organic Solvent Transfer
- Explosion-proof design meeting ATEX certification
- Fully enclosed transfer of ethanol, acetone and other solvents
- Safety advantage: Eliminates electrostatic spark risks
Key Technical Features
- Sanitary Design
- 316L stainless steel/PEEK materials with surface roughness Ra≤0.8μm
- CIP/SIP cleaning and sterilization capabilities
- Complies with FDA 21 CFR Part 11 electronic records requirements
- Intelligent Control System
- Automatic PID adjustment integrated with granulators
- Batch production data auto-recording and traceability
- 40% reduction in batch variation achieved in one solid dosage facility
- Low-Shear Transfer
- Protects sensitive polymer structures
- Particularly suitable for probiotic pellet coating
- Viability comparison: 25% improvement over gear pumps
Maintenance and Validation
- Replace sterile tubing per batch (USP Class VI compliant)
- Regular flow accuracy calibration (±2% error range)
- Annual PQ includes: Pulsation test, seal integrity verification
- Spare parts management with unique traceability coding